Angiotensin in 3D

Angiotensin is a hormone in the complex renin-angiotensin system of the body. This system is involved in maintaining blood pressure through kidney function-specifically water retention- and vessel constriction among other things. The Angiotensin II receptor is found in the kidney epithelial cells. Usually, Angiotensin molecules travel through the blood, into the kidney, and bind the receptors to cause vessel constriction and water retention.

Certain drugs that lower blood pressure, like Candesartan, can bind the angiotensin II receptors and block the downstream effects of the renin-angiotensin system. (high blood pressure). Here’s my depiction of this:

The purple rectangle represents the cell membrane, because the receptor sits in the cell membrane. The red molecule is Candesartan, binding the receptor. The blue molecules are the angiotensin hormone that are being blocked. I used a technique called sub surface scattering to put a texture on the molecules. This texture allows light to pass through to make the objects look a little gummy.

Picutre of author

About Claire Shapleigh, Biomedical Visualization

Hi, my name is Claire and I'm in my second year of the Biomedical Visualization MS program at UIC. It's a combination of art and science, and it's pretty fun. So far I've dissected a human body and learned how to draw in 2D using a computer AND my hand, and I'm about to learn how to 3D model. Holler at me if you have any questions about the program!

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